Budget impact analysis of niraparib and olaparib for maintenance treatment of platinum-sensitive,recurrent ovarian cancer in the US

Aims: This study aimed to evaluate the budget impact of niraparib and olaparib in patients with platinum-sensitive, recurrent ovarian cancer from a US third party payer perspective.

Materials and methods: A budget impact model was constructed to assess the additional per member per month (PMPM) costs associated with the introduction of niraparib and olaparib, two poly ADP-ribose polymerase ribose polymerase (PARP) inhibitors recently approved to be used in platinum-sensitive, recurrent ovarian cancer patients with and without a gBRCA mutation. The model assessed both pharmacy costs and medical costs. Pharmacy costs included adjusted drug costs, coinsurance, and dispensing fees. Medical costs included costs associated with disease monitoring and management of adverse events from the treatment. Epidemiological data from the literature were used to estimate the target population size. The analysis used 1-year time frame, and patients were assumed on treatment until disease progression or death. All costs were computed in 2017 USD. One-way sensitivity analyses were conducted to evaluate the model robustness.

Results: In a hypothetical plan of 1,000,000 members, 206 patients were estimated to be potential candidates for niraparib or olaparib maintenance treatment after applying all epidemiological parameters. At listed 30-day supply WAC prices of $14,750 for niraparib and $13,482 for olaparib, budget impacts of these two drugs were $0.169 PMPM and $0.156 PMPM, respectively, most of which were contributed by pharmacy costs. Sensitivity analyses suggested that assumptions around market share, platinum-sensitive rate after first treatment, and WAC prices affected results the most.

Limitations: In this model, it was assumed that adopting niraparib and olaparib would not affect utilization of existing medications. Also, the estimated clinical parameters from clinical trials could differ from real-world data.     

中国自然保护地规划的回顾与对比研究

中国自然保护地历经60余年的发展，形成了多部门主导、保护类型多样的自然保护地体系。面对机构改革和以国家公园为主体的自然保护地体系建立的契机，传统规划的经验积累为新规划体系的构建提供了借鉴的可能。通过回溯机构改革前各类自然保护地规划，对比分析其规划结构体系，并从人地关系视角切入，分析各类规划针对保护对象、保护利用强度,以及社会发展调控上的差异，总结各类自然保护地规划的既有经验，为新时期规划体系的重构提供支撑。     

基于无线生理传感器与虚拟现实技术的复愈性环境注意力恢复作用研究

基于卡普兰复愈性环境理论，运用脑机接口设备、智能腕带传感器等无线生理指标检测技术，测试大学生被试人群在沉浸式虚拟现实(VR)情境下，对4种复愈性环境及城市环境在注意力恢复和压力减轻方面的反应及其作用强度，获得被试在不同环境中脑电、心率、肌电的客观生理数据。采用非参数统计方法R语言对数据进行分析。结果显示，多数被试在复愈性环境中较城市环境表现出更好的注意力恢复效果。其中具有逃离性和迷人性特征的自然环境，复愈效果最为明显；在虚拟现实环境中，观赏城市环境图片也具有一定的复愈效果。     

Environmental Multi‐dimensionality and Staff Localization in Multinational Enterprises: The Case of Korean Firms

The person–environment fit theory posits that the term “environment” can be defined at different levels. This study delineates two environmental dimensions (strategic and organizational) and empirically examines the potential moderating effects of two strategic factors (intra‐ and inter‐regional diversification) on the relationship between two organizational factors (subsidiary ownership and host‐country experience) and MNE subsidiary staffing composition. The results indicate that strategic and organizational dimensions have impacts on subsidiary staffing composition. This study also finds that the interaction effects between strategic and organizational factors are significant only when there is congruence between demands from different environmental dimensions.     

Economic policy uncertainty and analysts’ forecast characteristics

We examine the influence of economic policy uncertainty (EPU) on the characteristics of analysts’ earnings forecasts over a thirty-year period, spanning a wide variety of political and economic conditions. Motivated by both theory and empirical evidence that suggest a decline in the quality of the information environment for firms as EPU increases, we establish that analysts’ forecast errors increase with EPU, as does the degree of forecast dispersion. Increased error and dispersion persist after controlling for several competing sources of economy-wide uncertainty. Cross sectional analysis exploring heterogeneity in forecast quality across both analyst and firm characteristics establishes that forecast error and dispersion increase with EPU across a broad spectrum of firms and levels of analyst expertise. We control for analysts’ experience overall and the years spent covering a particular industry and firm. Five alternative methods for classifying firms as policy sensitive versus policy neutral provide consistent evidence that analyst forecast errors and dispersion increase with EPU, even for firms not deemed to be particularly sensitive to policy.     

Bogotá's Left Turn: Counter-Neoliberalization in Colombia

For the political left, decentralization has increased both the appeal and the importance of governing the city, and yet sharp constraints limit the left's transformative potential when it controls that level of government alone. Bogotá is an important case in point under the recent mayoral administration of Gustavo Petro (2012–15), a demobilized guerrilla leader who sought to implement a series of urban policy reforms that together represent one of the most substantively radical and intellectually coherent attempts to challenge neoliberalism in all of Latin America. Focusing on the four policy arenas through which Petro hoped to transform the city (environment, housing, transport, and trash collection), the article documents the veto power of the firms whose privileges he threatened, as well as the tools through which they derailed reform. In contrast to the failure of his political economy agenda, Petro was indeed able to enact a number of progressive social policy reforms precisely because they did not threaten the profitability of the city's entrenched growth machine.     

Going green,going clean: Lean‐green sustainability strategy and firm growth

Despite the widespread recognition of the paybacks of “going green” and “going clean,” limited research has focused on the impact of lean‐green strategy on firm growth. In this study, we contribute to strategy and environmental sustainability literatures by investigating the possibility that the influence on lean‐green strategy and firm growth is driven by different levels of industry competition, managerial power, and family ties. Using panel data from 732 firms in four major industrialized economies (the United States, Germany, France, and the United Kingdom), we found that lean‐green strategy positively relates to firm growth and this relationship is amplified at higher levels of competition, managerial power, and family ties. Theoretical and practical implications of the study are also discussed.     

The intellectual structure of the journal Business Strategy and the Environment: A 25‐year author cocitation analysis

This article presents the intellectual structure and 25‐year author cocitation analysis of the journal Business Strategy and the Environment. The findings show that Business Strategy and the Environment is an emerging, well‐established journal in its field. The journal needs a core set of authors who are actively engaged in the production and certification of knowledge; further, it consists of a number of loosely linked research team contributors, each with its own areas of interest. The existence of these research teams is a sign of strength that characterizes the journal as it strives to foster a community of unified scholars whose published works advance our understanding of business strategic decisions and behavior with regard to the natural environment. This study is useful for contributors, readers, and editorial board members who form the journal's community of knowledge creation and certification.     

京津冀城市大气环境竞争力评价

从大气环境与城市竞争力的关联性入手,将大气环境风险、现状和治理纳入评价指标体系,基于组合权重的大气环境竞争力评价模型,对2013-2017年京津冀13个城市的大气环境竞争力水平进行了测评,并结合空间自相关分析和障碍度模型揭示了其空间效应及障碍因素。结果显示:京津冀城市大气环境竞争力存在明显的空间差异,呈"北部高、南部低、局部跳跃"格局,城市差距逐渐缩小;京津冀城市大气环境竞争力呈显著的空间集聚效应且存在正向相关性,空间分布格局相对稳定。     

互文性理论视角下大学英语写作教学方法探析

互文性理论认为每个语篇都是对其他语篇的吸收和转化，语篇不是孤立的，总是存在于语篇网络中。互文性是西方结构主义和后现代主义文化思潮中产生的文本理论，但是目前对于互文性理论的研究多以文学批评理论的研究和文学作品研究为主，作为教学策略应用于英语教学的研究则为数不多。本文通过探讨互文性理论指导下大学英语写作教学的实践意义及目前大学英语写作教学存在的问题，提出了笔者在教学实践中所积累的几点写作教学法，以期为大学英语写作教学模式提供新的思路。